American journal of rhinology & allergy
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Am J Rhinol Allergy · Nov 2021
Association of Air Pollutant Exposure and Sinonasal Histopathology Findings in Chronic Rhinosinusitis.
Ambient air pollution is well known to cause inflammatory change in respiratory epithelium and is associated with exacerbations of inflammatory conditions such as asthma and chronic obstructive pulmonary disease. However, limited work has been done on the impact of air pollution on pathogenesis of chronic rhinosinusitis and there are no reports in the literature of how pollutant exposure may impact sinonasal histopathology in patients with chronic rhinosinusitis. ⋯ Exposure to ambient air pollutants may contribute to pathogenesis of CRS. Increasing ozone exposure was linked to both higher tissue inflammation and presence of eosinophilic aggregates and Charcot-Leyden crystals in CRSwNP patients.
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Am J Rhinol Allergy · Jul 2021
Quantification of Aerosol Particle Concentrations During Endoscopic Sinonasal Surgery in the Operating Room.
Recent indirect evidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmission during endoscopic endonasal procedures has highlighted the dearth of knowledge surrounding aerosol generation with these procedures. As we adapt to function in the era of Coronavirus Disease 2019 (COVID-19) a better understanding of how surgical techniques generate potentially infectious aerosolized particles will enhance the safety of operating room (OR) staff and learners. ⋯ Drilling and microdebrider use during endonasal surgery in a standard operating room is associated with a significant increase in airborne particle concentrations. Fortunately, this increase in aerosol concentration is localized to the area of the operating surgeon, with no detectable increase in aerosol particles at other OR positions.
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Am J Rhinol Allergy · Jan 2021
ReviewViral Infections of the Upper Airway in the Setting of COVID-19: A Primer for Rhinologists.
Viral respiratory tract infections are associated with a significant burden of disease and represent one of the leading causes of mortality worldwide. The current Coronavirus Disease 2019 (COVID-19) pandemic highlights the devastating toll that respiratory viruses have on humanity and the desperate need to understand the biological characteristics that define them in order to develop efficacious treatments and vaccines. To date, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has infected nearly 600 times more people and resulted in 200 times more deaths relative to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV) combined. ⋯ In light of these unprecedented times, the need to understand the nuances of these viral respiratory pathogens, especially SARS-CoV-2, cannot be overemphasized. This knowledge base is of particular importance to otolaryngologists, whose expertise in the upper airway coincides with the anatomic tropism of these infectious agents.
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Am J Rhinol Allergy · Sep 2020
Multicenter StudyPrevalence and Recovery From Olfactory and Gustatory Dysfunctions in Covid-19 Infection: A Prospective Multicenter Study.
Covid-19 is defined by an association of multiple symptoms, including frequently reported olfactory and gustatory disorders. ⋯ Olfactory and gustatory dysfunctions related to Covid-19 are frequently reported and prevalent in mild symptomatic forms of the disease. Recovery in most cases seems rapid and complete.
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Am J Rhinol Allergy · Jul 2020
Correlations in Trends of Sinusitis-Related Online Google Search Queries in the United States.
Online search query trends have been shown to correlate with real-life epidemiologic phenomena. ⋯ Trends in Google online search volumes over time of "sinusitis" symptomatology mimic real-world clinical phenomena and provide insight into the issues affecting the general population.