Scandinavian journal of infectious diseases
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Scand. J. Infect. Dis. · Nov 2012
Changes in the aerobic faecal flora of patients treated with antibiotics for acute intra-abdominal infection.
An open observational study was performed to investigate changes in the rectal flora and antibiotic susceptibility among faecal bacteria in patients treated with antibiotics for acute intra-abdominal infection. ⋯ Following antibiotic treatment, a shift in the aerobic rectal flora to species with intrinsic antibiotic resistance was observed. This indicates that the emergence of resistance is not due to new mutations, but rather to selection of more resistant species. This should be taken into account when designing treatments for secondary intra-abdominal infections.