Journal of nuclear medicine : official publication, Society of Nuclear Medicine
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Randomized Controlled Trial Comparative Study Clinical Trial
Opioid and opioid-like drug effects on whole-gut transit measured by scintigraphy.
We studied the effects of several drugs on gastrointestinal transit (tramadol HCl, acetaminophen with codeine and placebo) in a randomized, double-blind, crossover study. ⋯ Tramadol and APAP/C had no effect on gastric emptying or small bowel transit. At equianalgesic doses, tramadol caused less delay in colonic transit than APAP/C for 48 hr and delay in the GC agreed with the subjective complaints of constipation on both drugs.