Journal of nuclear medicine : official publication, Society of Nuclear Medicine
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Comparative Study
Value of FDG PET in papillary thyroid carcinoma with negative 131I whole-body scan.
The management of metastatic thyroid carcinoma patients with a negative 131I scan presents considerable problems. Fifty-four athyrotic papillary thyroid carcinoma patients whose 1311 whole-body scans were negative underwent 18F-fluorodeoxyglucose (FDG) PET; the purpose was to determine whether this procedure could localize metastatic sites. We also assessed its usefulness in the management of these patients. ⋯ FDG PET scan localized metastatic sites in 131I scan-negative thyroid carcinoma patients with high accuracy. In particular, it was superior to 131I whole-body scan and serum thyroglobulin measurement for detecting metastases to cervical lymph nodes. FDG PET was helpful for determining the surgical management of these patients.
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Comparative Study
Evaluation of glutathione localization in brain using 99mTc meso-HMPAO.
The relationship between distribution of 99mTc meso-hexamethyl propyleneamine oxime (HMPAO) and glutathione (GSH) content was studied in the mouse. ⋯ 99mTc meso-HMPAO might be used as an imaging agent to assess GSH localization in the brain.