Journal of nuclear medicine : official publication, Society of Nuclear Medicine
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Whether (18)F-FDG PET can detect inflammation in the coronary arteries remains controversial. We examined (18)F-FDG uptake at the culprit sites of acute myocardial infarction (AMI) after percutaneous coronary stenting (PCS) by coregistering PET and coronary CT angiography (CTA). ⋯ Systematic fusion of (18)F-FDG PET and coronary CTA demonstrated increased culprit site (18)F-FDG uptake more commonly in patients with AMI than in patients with stable CAD. However, this approach failed to detect increased signal at the culprit site in nearly half of AMI patients, highlighting the challenging nature of in vivo coronary artery plaque metabolic imaging. Nonetheless, our findings suggest that imaging of coronary artery inflammation is feasible, and further work evaluating (18)F-FDG uptake in high-risk coronary plaques prior to rupture would be of great interest.
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Clinical Trial
Multifunctional profiling of non-small cell lung cancer using 18F-FDG PET/CT and volume perfusion CT.
The aim of this study was to investigate correlations between glucose metabolism registered by (18)F-FDG PET/CT and tumor perfusion quantified by volume perfusion CT and immunohistochemical markers Ki67 and microvessel density (MVD) in patients with non-small cell lung cancer (NSCLC). ⋯ (18)F-FDG uptake correlates with Ki67, whereas BF, BV, and K(trans) correlate with MVD. Therefore, (18)F-FDG uptake and perfusion parameters provide complementary functional information. An improved tumor profiling will be beneficial for both prognosis and therapy response evaluation in these tumors.