Annals of physical and rehabilitation medicine
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Ann Phys Rehabil Med · Sep 2019
Meta AnalysisEfficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: A systematic review and meta-analysis.
Exercise is an effective treatment for osteoarthritis. However, the effect may vary from one patient (or study) to another. ⋯ Exercise significantly reduces pain and improves function, performance and QoL in people with knee and hip OA as compared with usual care at 8 weeks. The effects are maximal around 2 months and thereafter slowly diminish, being no better than usual care at 9 to 18 months. Participants with younger age, knee OA and not awaiting joint replacement may benefit more from exercise therapy. These potential determinants, identified by study-level analyses, may have implied ecological bias and need to be confirmed with individual patient data.
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Ann Phys Rehabil Med · Sep 2019
Young adults' perspectives on health-related quality of life after paediatric traumatic brain injury: A prospective cohort study.
Quality of life (QoL) is commonly affected in children and families living with traumatic brain injury (TBI). Despite the established link between childhood TBI and reduced health-related QoL (HRQoL), there is a dearth of longitudinal, prospective research to determine the prevalence and predictors of impaired HRQoL in the very long term post-injury. ⋯ A substantial proportion of young adult survivors of childhood TBI experience poor HRQoL in at least one domain of functioning at 15 years post-injury. These findings suggest that, even in the very long term post-injury, the identification and treatment of modifiable risk factors has potential to improve very-long-term HRQoL outcomes in this vulnerable population.