Journal of surgical oncology
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Review Comparative Study
Adjuvant aromatase inhibitor therapy for early breast cancer: A review of the most recent data.
Tamoxifen is the established adjuvant treatment for postmenopausal women with hormone-sensitive early breast cancer. However, the side-effects associated with tamoxifen therapy have prompted a search for safer and potentially more effective endocrine agents. Results from randomized trials of the third-generation aromatase inhibitors, anastrozole, letrozole and exemestane, demonstrating improved efficacy compared with tamoxifen and favorable tolerability profiles, are discussed in this review.
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Who should undergo a completion dissection following identification of a +sentinel lymph node (SLN) is controversial. ⋯ A definitive answer to the question of who needs a completion axillary dissection awaits the results of ongoing trials. In the interim, our data does not support eliminating dissection for any subgroup of patients with +SLNs.
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Editorial Comment Review
Transthoracic vs. transhiatal esophagectomy: Stage migration muddies the water.