Injury
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Bone tissue engineering is a fast-growing field in regenerative medicine. Consequently, there is a high demand for new, fast and reliable methods to track and quantify the osteogenic differentiation of cells. Recently, a novel method was published to non-destructively quantify the hydroxyapatite content of monolayer and 3-dimensional mesenchymal stem cell cultures using the ability of 99mTechnetium-methylene diphosphonate (MDP), a well-established tracer in clinical nuclear medicine, to bind to newly synthesized hydroxyapatite. ⋯ This revealed a highly significant difference between the three osteogenic groups at each timepoint compared to their corresponding negative controls. However, there was no statistically significant difference between the three different tracers (MDP, DPD, HDP) in the osteogenic groups. Therefore all three tracers are of similar value when quantifying the extracellular hydroxylapatite content in osteogenic stem cells cultures.
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Due to aging society, osteoporotic posterior ring fractures of the pelvis are gaining importance. Percutaneous iliosacral screw fixation can reduce pain if conservative therapy is not sufficient. One of the surgical complications is the malposition of the screws in neuroforamen. The aim of this study is to correlate the measured pedicle angle with the screw position in postoperative CT scans. ⋯ Complications such as intraforaminal screw position and revision surgery are more frequent in patients with steeper S1 pedicles, making this a detrimental prognostic marker.
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Randomized Controlled Trial
Dorsal bridge plating versus bridging external fixation for management of complex distal radius fractures.
Distal radius fractures are the most frequent upper limb injuries encountered by orthopedic surgeons. Surgical treatment of distal radius fractures is preserved for unstable and displaced fractures. A randomized controlled trial was conducted to compare the radiological and functional outcomes of bridge plating (BP) to external fixation (EF) in comminuted intra-articular distal radius fractures. ⋯ In comparison to external fixation, bridge plating may provide earlier functional recovery with lower complication rates. However, no functional or radiological superiority were demonstrated at 12-months follow-up.
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The use of one midline incision versus dual medial/lateral incisions for dual plating of bicondylar tibial plateau (BTP) fractures is controversial. This study aimed to compare rates of infection and secondary surgery in patients treated with dual plating for a BTP fracture using a single versus double incisions. ⋯ III.