Chest
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A 53-year-old woman had a serious air embolism from the central venous catheter tract after lung transplantation. Lung transplant patients appear to be at increased risk for this complication, and four other known cases are reported.
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To investigate the initial and long-term effect of nitric oxide (NO) inhalation in patients with severe acute respiratory distress syndrome (ARDS). ⋯ Beneficial effects of NO inhalation can be observed in most patients with severe ARDS; in some cases, however, it may fail to improve pulmonary gas exchange or to reduce pulmonary hypertension without obvious explanation. To demonstrate a possible increase in survival associated with NO inhalation, large randomized prospective trials are required.
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A number of echocardiographic clues of pericardial tamponade have been described, but their accuracy in patients with pulmonary hypertension has not been well elucidated. Four echocardiographic clues of pericardial tamponade, namely, right atrial collapse (RAC), right ventricular diastolic collapse (RVDC), marked (> 40%) respiratory variation in transmitral Doppler flow velocity ("flow velocity paradoxus [FVP]"), and inferior vena cava plethora (IVCP) were prospectively evaluated in 32 patients with large pericardial effusions. Of 12 patients with pulmonary hypertension, 6 had invasively determined evidence of tamponade and 6 did not; of 20 patients without pulmonary hypertension, 11 had tamponade and 9 did not. ⋯ Although all predictive accuracies were lower in patients with pulmonary hypertension, statistically significant decreased predictive accuracy was found only with FVP (p < 0.05). Interestingly, IVCP had the best predictive accuracy among patients with pulmonary hypertension. Our findings suggest that despite somewhat decreased accuracy in patients with pulmonary hypertension, traditional echocardiographic clues for pericardial tamponade may be useful.
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Mixed venous oxygen saturation (SvO2) is a physiologic parameter reflecting cardiac output (CO) and tissue oxygen utilization. An implantable oxygen sensor incorporated in a right ventricular pacing lead has been developed to assess the feasibility of ambulatory monitoring of SvO2 to predict cardiorespiratory parameters. Eight patients with a mean age of 62 +/- 2 years and sinoatrial disease received an SvO2-driven dual-chamber rate-adaptive pacemaker capable of continuous SvO2 measurement. ⋯ Doppler-derived CO was significantly correlated with CO estimated from SvO2 measured (r = 0.8 +/- 0.1, p < 0.05) and is expressed as 46x derived CO +300. Although continuous SvO2 sensing was originally developed to increase pacing rate during exercise, its use can be extended for monitoring cardiopulmonary performance on an ambulatory basis. This may be useful as a direct assessment of cardiopulmonary status in diseased states and also as an objective means to evaluate cardiac response to medical therapy in patients with heart failure.