Chest
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Multicenter Study Comparative Study
Obstructive Sleep Apnea and Coronary Plaque Characteristics.
Virtual histology intravascular ultrasound (VH-IVUS) is an intravascular imaging technique that enables the characterization of coronary plaques. We sought to determine the association between OSA and coronary plaque characteristics in patients presenting with coronary artery disease. ⋯ In patients presenting with coronary artery disease, moderate to severe OSA was independently associated with a larger total atheroma volume in the target coronary artery. Further studies on the effects of CPAP on total atheroma volume are warranted.
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Multicenter Study
INCREASED RISK OF EXACERBATION AND HOSPITALIZATION IN SUBJECTS WITH AN OVERLAP PHENOTYPE: COPD-ASTHMA.
Several COPD phenotypes have been described; the COPD-asthma overlap is one of the most recognized. The aim of this study was to evaluate the prevalence of three subgroups (asthma, COPD, and COPD-asthma overlap) in the Latin American Project for the Investigation of Obstructive Lung Disease (PLATINO) study population, to describe their main characteristics, and to determine the association of the COPD-asthma overlap group with exacerbations, hospitalizations, limitations due to physical health, and perception of general health status (GHS). ⋯ The coexisting COPD-asthma phenotype is possibly associated with increased disease severity.