Chest
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Pulmonary Hypertension Posters IISESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: Pulmonary arterial hypertension (PAH; OMIM 178600) is a rare disorder characterized by obstruction of precapillary pulmonary arteries. PAH results from extensive remodelling of the pulmonary vasculature caused by an increased musculation and the fibrosis of the intima that leads to obliteration of small pulmonary arteries. The 75% of patients with familial form of PAH have a mutation in the gene encoding bone morphogenetic protein receptor type II (BMPR2). However, some other candidate genes have been advocated, including the KCNA5 gene that codifies for a potassium voltage-gated channel and ACVRL (Activin A receptor type II-like 1). These genes are located on chromosomes 12p13 and 12q13 respectively. ⋯ The following authors have nothing to disclose: Guillermo Pousada, Adolfo Villar, Carlos Vilariño, Diana ValverdeNo Product/Research Disclosure Information.
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Infectious Diseases CasesSESSION TYPE: Case ReportsPRESENTED ON: Saturday, March 22, 2014 at 04:15 PM - 05:15 PMINTRODUCTION: Daptomycin is a semisynthetic lipopeptide antibiotic, the first to be marketed, used to treat gram-positive bacterial infections, specifically skin and soft tissue infections or Staphylococcus aureus bacteremia and right-sided endocarditis. Although it cannot be used in the treatment of pneumonia, due to inactivation by pulmonary surfactant, in isolated cases it has been associated with life-threatening eosinophilic pneumonia. The majority of reported cases have high levels of serum eosinophilia. We report a case of daptomycin induced eosinophilic pneumonia without elevated serum eosinophilia. ⋯ In those patients whom daptomycin is used, we must be aware of potentially life threatening daptomycin induced lung disease, even in the absence of eosinophilia. Immediate recognition is vital as discontinuation of the offending agent alone can quickly resolve the lung disease.Reference #1: Eosinophilic pneumonia in patients treated with daptomycin: review of the literature and US FDA adverse event reporting system reports. Kim PW, et al. Drug Saf. 2012 Jun 1;35Reference #2: Package insert. Cubicin (daptomycin). Lexington, MA: Cubist Pharmaceuticals. Aug 2010DISCLOSURE: The following authors have nothing to disclose: Anita Rajagopal, Edward Mintz, Lindsey ReeseNo Product/Research Disclosure Information.
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COPD Rehabilitation PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: In elderly patients the association between chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD) is common and predisposes to severe complications and marked restrictions of daily activity. The aim was to evaluate the results of exercise training of the rehabilitation programs in patients with mild or moderate COPD and stable chronic ischemic heart disease (CIHD). ⋯ The following authors have nothing to disclose: Corina Cozma Dima, Clementina Doina Cojocaru, Paraschiva PostolacheNo Product/Research Disclosure Information.
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Symptoms of Respiratory Disease PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: The purpose of our work is to determine the profile of patients most likely to develop these episodes taking into account obstructive airway problems such as asthma or COPD as the most common and therefore investigated the airway eosinophilic inflammation (asthma type cough and eosinophilic bronchitis) as well as active smoking or the presence of chronic airflow obstruction (CAO). ⋯ The following authors have nothing to disclose: Carolina Gotera, Carolina Jurkojc Mohremberger, Adalberto PachecoNo Product/Research Disclosure Information.
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Pleural CasesSESSION TYPE: Case ReportsPRESENTED ON: Sunday, March 23, 2014 at 09:00 AM - 10:00 AMINTRODUCTION: Neurofibromatosis is an autosomal dominant syndrome. Lateral thoracic meningocele (LTM) is rare but is known to be associated with neurofibromatosis type 1 upto 68.8%1 of times. Here we present an unusual case of pleural drain placement in LTM which mimicked a loculated pleural effusion. ⋯ Large LTM may look like loculated pleural effusion on imaging. In patients with neurofibromatosis, LTM should be considered in the differentials of loculated pleural effusion.Reference #1: de Andrade e al. Giant intrthoracic meningoceles associated with cutaneous neurofibromatosis type I. Arq Neuropsiquiatr. 2003 Sep;61(3A):677-81. Epub 2003 Sep 16Reference #2: M. Kubota, N. Saeki, A. Yamaura. Lateral thoracic meningocele presenting as a retromediastinal mass. Br. J Neurosurgery Dec;16(6):607-8DISCLOSURE: The following authors have nothing to disclose: Naveed Sheikh, Dipaben Modi, Micheal McCormmackNo Product/Research Disclosure Information.