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Critical Care Posters IISESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: We have previously demonstrated in a clinically relevant murine model of sepsis, that a phenotype of left ventricular (LV) dilation was associated with improved cardiovascular performance (stroke volume (SV) and cardiac output (CO)) and increased survival. Using the same model of sepsis, we sought to determine whether survival in mice that did not manifest dilation was associated with a particular phenotype. ⋯ The following authors have nothing to disclose: Fabien Picard, François Depret, Sergio Zanotti-Cavazzoni, Steven HollenbergNo Product/Research Disclosure Information.
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Critical Care Posters IISESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: Echocardiography is an important tool for evaluating cardiac and hemodynamic functions in small animals but requires sedation and immobility, which influences cardiac performance. Minimizing the hemodynamic effects of anesthesia is extremely important for improving applicability of animal models to the clinical setting, especially in models of shock. We aimed to evaluate the effects of isoflurane dose on myocardial function in a murine model, and to attempt to compare very low doses of isoflurane to a state in which the mice were off anesthesia. ⋯ The following authors have nothing to disclose: Fabien Picard, François Depret, Sergio Zanotti-Cavazzoni, Steven HollenbergNo Product/Research Disclosure Information.