Chest
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The mutations in oncogenic genes, such as EGFR, ALK, BRAF, HER2, DDR2, RET, and AKT1, defined subsets of non-small cell lung cancers (NSCLCs) with potential sensitivity to targeted therapies. At present, the mutational spectrum, prevalence, and clinicopathologic characteristics in squamous cell carcinomas with minor (<10%) glandular component (SQCC-mGCs) are not well established. ⋯ Our results demonstrated that oncogenic mutations in EGFR, KRAS, BRAF, HER2, and ALK were extremely rare or absent in patients with pure SQCC, whereas SQCC-mGC had a relatively high frequency of EGFR, ALK, or KRAS mutations. Prospective identification of these known oncogenic mutations in SQCC-mGC before the initiation of treatment is an essential step to identify which patient could benefit from targeted therapies.
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Tuberculosis Case Report PostersSESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMPURPOSE: To diagnose and treat a young patient with superior vena cava syndrome ⋯ The following authors have nothing to disclose: Roxana Nemes, Emilia Tabacu, Paraschiva PostolacheNo Product/Research Disclosure Information.
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Case Reports
A case of pulmonary hemorrhage due to drug-induced pneumonitis secondary to ticagrelor therapy.
We report a case of significant pulmonary hemorrhage developing shortly after commencing ticagrelor and aspirin therapy and requiring coronary artery bypass grafting to safely cease the antiplatelet therapy. Lung biopsy findings were consistent with drug-induced lung injury. Clinicians should be aware of this significant adverse event with this drug class.
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Bronchoscopy and Interventional Procedures PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: Fiber-optic bronchoscopy is an invasive procedure performed to identify possible endobronchial lesions. Diabetic patients often present with non-resolving pneumonia and collapse, many of whom are elderly and smoker; thus always giving rise to the suspicion of malignancy. ⋯ The following authors have nothing to disclose: Jamal AhmedNo Product/Research Disclosure Information.
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COPD Rehabilitation PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: Introduction: Despite the proven benefits of pulmonary rehabilitation programs (PR), these show a considerable drop-out and low attendance. Objectives: To identify the characteristics of patients with poor adherence to a specific COPD rehabilitation program. ⋯ The following authors have nothing to disclose: Virginia Almadana, Concepcion Romero, Agustin Valido, Ana Gómez-Bastero, Jesús Sánchez, Teodoro MontemayorNo Product/Research Disclosure Information.