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Pulmonary Hypertension Posters IISESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: The prevalence of PAH in patients with IPF is not well known. There has been no prospective study to date. The purpose of our study was to know the prevalence of PAH in patients with IPF at any stage of severity ⋯ 60 patients (18 women, age at diagnosis 64 years) were included and 56 completed the study protocol. Patient characteristics: FVC 64%, DLCO 41%, 6MWT 357 meters, systolic pulmonary arterial pressure 46 mmHg. 17 patients showed a systolic pulmonary artery pressure greater than 40 mmHg and in 14 of them PAH was confirmed by right heart catheterization with a mean pulmonary arterial pressure of 28.6 mmHg. When comparing various clinical and functional parameters between patients with and without PAH significant differences were seen in FVC, FEV1, DLCO, 6MWT and Functional Class. In a multivariate analysis DLCO was associated with the presence of PAHCONCLUSIONS: PAH is not infrequent in patients with IPF (around 26%).Patients with more severe disease are more likely to develop PAH. A marked decrease in DLCO is independently associated with the presence of PAHCLINICAL IMPLICATIONS: PAH is a devastating disease with prognostic and therapeutic implications in patients with IPF. To know the prevalence and associated factors in very important for a better management of this patients because we now have effective treatments in PAHDISCLOSURE: The following authors have nothing to disclose: Adolfo Villar, Julio Ancochea, Antonio XaubetNo Product/Research Disclosure Information.
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OSA PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: A cross-sectional review was performed in order to assess the ability of the neck circumference (NC) to predict the diagnosis of obstructive sleep apnoea syndrome (OSAS) in a population group from Timisoara, Romania. ⋯ The following authors have nothing to disclose: Stefan Mihaicuta, Izabella Anita Toth, Sorin ParalescuNo Product/Research Disclosure Information.
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Tuberculosis PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: The efficacy of standard chemotherapy for Mycobacterium avium complex pulmonary disease (MAC-PD) is limited by poor clinical response rate, drug toxicity and side effects. When to start standard chemotherapy or which patients to treat remains undefined. In Japan, patients with MAC-PD are sometimes treated with erythromycin alone as an alternative therapy before or after standard chemotherapy to prevent disease progression. The rationale for this is that erythromycin has immunomodulatory properties independent of its antimicrobial effects. To date, however, monotherapy with erythromycin for MAC-PD is not well established. Therefore we investigated the safety, tolerability and possible clinical benefit of this treatment. ⋯ The following authors have nothing to disclose: Yukihiro Yano, Seigo Kitada, Masahide Mori, Soichiro Yokota, Ryoji MaekuraNo Product/Research Disclosure Information.
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Cancer Case Report Posters IISESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: Organizing Pneumonia is a rare immune disorder characterized by granulation tissue that obstructs small bronchioles and extends into the distal alveolar ducts and alveoli. Though many causes have been described in literature, its association with lymphoma is rare. ⋯ The following authors have nothing to disclose: Vishesh Paul, Jay Lipshitz, Michael BergmanNo Product/Research Disclosure Information.
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Lung Cancer Posters ISESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: Tobacco smoke exposure is the main risk factor for the development of lung cancer (LC) and chronic obstructive pulmonary disease (COPD). In turn, COPD is a risk factor for the development of LC. Tobacco smoke contains a large number of free radicals, reactive oxygen species and reactive nitrogen species that increase oxidative stress. Damage to membrane lipids (lipid peroxidation) produces different volatile organic compounds (VOC) (aldehydes, carboxylic acids, etc.) that can be detected in exhaled breath. ⋯ Propanoic acid in exhaled breath samples could be used to discriminate between lung cancer patients without and with COPD. Further studies are required to confirm this hypothesis. Supported by FIS (Formación en Investigación en Salud): PI07/1116; Neumomadrid 2008 and 2012, SEPAR (Sociedad Española de Neumonología y Cirugía Torácica) 2009/881 and 2012/135CLINICAL IMPLICATIONS: New biomrkers involved in lung cancer screening and other respiratory diseases (COPD)DISCLOSURE: The following authors have nothing to disclose: Carolin Wagner, Maria Angeles Munoz, Javier Jareño, Carlos Gutierrez Ortega, Antonio Aguilar Ros, Belen Carrillo Aranda, Jose Angel Maldonado Sanz, Concepcion Civera, Luis CallolVOCs are used in the evaluation of respiratory diseases such as lung cancer, COPD.