Chest
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Review Meta Analysis
Sarcoidosis and cancer risk: systematic review and meta-analysis of observational studies.
An increased cancer risk in patients with sarcoidosis has been suggested, although results are conflicting in a number of case-control and cohort studies. We conducted a systematic review of all available data and performed a meta-analysis to better define and quantify the association between sarcoidosis and cancer. ⋯ The present meta-analysis suggests a significant, though moderate, association between sarcoidosis and malignancy.
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Review Meta Analysis
Is Quadriceps Endurance Reduced in COPD?: A Systematic Review.
Although the aerobic profile of the quadriceps muscle is reduced in COPD, there is conflicting evidence regarding whether this leads to reduced quadriceps muscle endurance. We, therefore, performed a systematic review of studies comparing quadriceps endurance in individuals with COPD with that in healthy control subjects. ⋯ Quadriceps endurance is reduced in individuals with COPD compared with healthy control subjects, independent of the type of task performed.
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Review Meta Analysis
SELF-MANAGEMENT FOLLOWING AN ACUTE EXACERBATION OF COPD: A SYSTEMATIC REVIEW.
Self-management (SM) reduces hospital admissions in patients with stable COPD. However, its role immediately post-acute exacerbation (AE) is unclear. The objectives of this review were to describe SM interventions delivered immediately following an AE of COPD (AECOPD) and to conduct a systematic review with meta-analysis of its impact on health-care utilization and health outcomes. ⋯ SM interventions delivered immediately post-AE vary widely and outcome measures are inconsistent, making it difficult to draw strong recommendations regarding its effectiveness. The evaluation of SM interventions, delivered by trained health-care professionals to selected patients and which offer structured follow-up, appears necessary.
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Randomized Controlled Trial
Family-based psychosocial support and education as part of pulmonary rehabilitation in COPD: a randomized controlled trial.
Involving family as part of the patient's rehabilitation plan of care might enhance the management of COPD. The primary aim of this study was to investigate the impact of a family-based pulmonary rehabilitation (PR) program on patients and family members' coping strategies to manage COPD. ⋯ This research supports family-based PR programs to enhance coping and psychosocial adjustment to illness of the family system.
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Lymphangioleiomyomatosis (LAM) is characterized by the proliferation in the lung, axial lymphatics (eg, lymphangioleiomyomas), and kidney (eg, angiomyolipomas) of abnormal smooth muscle-like LAM cells, which express melanoma antigens such as Pmel17/gp100 and have dysfunctional tumor suppressor tuberous sclerosis complex (TSC) genes TSC2 or TSC1. Histopathologic diagnosis of LAM in lung specimens is based on identification of the Pmel17 protein with the monoclonal antibody HMB-45. ⋯ Based on its sensitivity and specificity, αPEP13h may be useful in the diagnosis of LAM and more sensitive than HMB-45.