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There is an ongoing debate about whether clearance of Mycobacterium tuberculosis infection occurs and at what magnitude. Recent studies quantifying 'uncertainty zones' of interferon-gamma release assays (IGRA) provide a more stringent estimate of reversion, potentially indicating clearance. ⋯ These results suggest high annual rates of IGRA reversion, even with the use of 'uncertainty zones'; reversion rates decreased with time from exposure and at older ages.