Chest
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Pulmonary and Sleep MedicineSESSION TYPE: Slide PresentationPRESENTED ON: Saturday, March 22, 2014 at 09:00 AM - 10:00 AMPURPOSE: Intermittent hypoxia and increase sympathetic activity during apnea episodes may cause systemic inflammation via down-regulation of regulatory T-cell (Treg cells). This may contribute to premature atherosclerosis leading to an increase in the size of arterial intima-media thickness (IMT). To evaluate the relationship between Treg plasma cells and intima-media thickness (IMT) in non-OSA and OSA patients without comorbidities ⋯ The effect of nocturnal intermittent hypoxia and increase sympathetic activity is not homogeneous among all patients with OSA. It seems that a subset of patients exhibit an increased risk of subclinical atherosclerosis associated with a down-regulation of regulatory T-cells. This subgroup of patients probably represents a particular phenotypic presentation of OSA that merits a specific treatment. Supported by ISCIII grant PI12/02175 and SEPAR-2014DISCLOSURE: The following authors have nothing to disclose: Marta Marin-Oto, Teresa Martin, Javier Godino, Marta Andres, Victoria Gil, Jose MarinNo Product/Research Disclosure Information.
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Tuberculosis Case Report PostersSESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: Pulmonary tuberculosis is an ancient contagious disease which remains a public health issue due to a large reservoir of latent infection (1). ⋯ So, we should always treat tuberculosis as a life-threatening infectious disease which remains a major global health issue, especially due to dormant bacteria.Reference #1: WHO 2010. Global tuberculosis control-surveillance, planning, financing. Geneva, Switzerland: WHO.Reference #2: Allwood BW, Myer L, Bateman ED A Systematic Review of the Association between Pulmonary Tuberculosis and the Development of ChronicAirflow Obstruction in Adults. Respiration. 2013 May 3DISCLOSURE: The following authors have nothing to disclose: Bianca Paraschiv, Claudia Lucia Toma, Stefan Dumitrache-Rujinski, Liliana Grigoriu, Ionela Nicoleta Belaconi, Codin Saon, Miron Alexandru BogdanNo Product/Research Disclosure Information.
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Pulmonary Vascular Case Report PostersSESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: Klippel-Trenaunay-Weber syndrome (KTWS) is a rare congenital condition characterized by extensive venous malformations and soft tissue and bone hypertrophy. KTWS predisposes to hypercoagulable states, including venous thromboembolism (VTE) and pulmonary embolism (PE). The incidence of PE ranges from 14-22 %; however, recurrent massive PE is unusual. We report the case of an adult female with KTWS who developed recurrent massive PE and was successfully treated with thrombolytic therapy. ⋯ This rare congenital condition and associated complications can at times be difficult to manage. The management of prophylaxis for PE recurrence is an area that needs special attention.Reference #1: Adriane Gianlupi, MD; Richart W. Harper, MD; Denis M. Dwyre, MD; Gregory P. Marelich, MD, FCCP, "Recurrent Pulmonary Embolism Associated With Klippel-Trenaunay-Weber Syndrome" Chest. 1999;115(4):1199-1201. doi:10.1378/chest.115.4.1199Reference #2: Erin E. Huiras, MD, Cheryl J. Barnes, MD, Lawrence F. Eichenfield, MD, Andrew N. Pelech, MD, Beth A. Drolet, MD, "Pulmonary Thromboembolism Associated With Klippel-Trenaunay Syndrome" Published online September 15, 2005 PEDIATRICS Vol. 116 No. 4 October 1, 2005 pp. e596 -e600Reference #3: Mikula, N, Gupta, SM, Miller, M, et al Klippel-Trenaunay-Weber syndrome with recurrent pulmonary embolism.Clin Nucl Med1991;16,253-255DISCLOSURE: The following authors have nothing to disclose: Abhay Vakil, Khalid Sherani, Viral Patel, Kelly Cervellione, Mohammed BaburyNo Product/Research Disclosure Information.
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Lung Cancer IISESSION TYPE: Slide PresentationsPRESENTED ON: Sunday, March 23, 2014 at 12:15 PM - 01:15 PMPURPOSE: Biomarkers are of importance for understanding the biology of disease and in diagnosis and treatment planning. MicroRNAs are short non-coding ribonucleotide chains which modify the expression of multiple genes and pathways. MicroRNAs in BAL and bronchial washings may prove useful as prognostic/ predictive and monitoring markers. However, microRNA measurements in these samples have yet to be established. We present data from a pilot study in which microRNAs implicated in lung cancer were measured. ⋯ S. Kaduthanam: Grant monies (from sources other than industry): grant from federal ministry Ruprecht Kuner: Grant monies (from sources other than industry): grant from federal ministry The following authors have nothing to disclose: Amanda Tufman, Fernando Gamarra, Rosi Kiefl, Rudolf Huberresearch on potential biomarkers and pathogenesis of lung diseases.
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Cardiovascular Case Report Posters ISESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: Cafergot is an ergotamine commonly prescribed to treat migraine headaches. As a serotonin agonist, it works at 5-HT2B receptors to cause selective vasoconstriction. In this case, a 62 YO WF who had been taking Cafergot for 15 years developed sudden onset transudative recurrent pleural effusions, all common causes ruled out by negative cytology, chemistry, culture, and cell count. She eventually developed severe multiple valvulopathy, pulmonary hypertension, and congestive hepatopathy. This case is unique in its presentation with recurrent pleural effusions of unknown etiology, with delayed diagnosis of ergotamine-induced valvulopathy given its slow progression. ⋯ The following authors have nothing to disclose: Rachel Felber, Hassan BencheqrounNo Product/Research Disclosure Information.