International forum of allergy & rhinology
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Int Forum Allergy Rhinol · Aug 2016
HLA-DRB1*08:03:02 and HLA-DQB1*06:01:01 are associated with house dust mite-sensitive allergic rhinitis in Chinese subjects.
Allergic rhinitis (AR) is a multifactorial immunologic disease that is influenced by both genetic and environment factors. House dust mites (HDMs) are important inhalant aeroallergens and are an epidemiologic risk factor for AR. Similarly, the human leukocyte antigen (HLA) class II genes DQB1 and DRB1 have been shown to be associated with AR and play an important role in the regulation of the immune response. The objective of this work was to elucidate the HLA-II gene alleles associated with AR in HDM-sensitive Han Chinese subjects. ⋯ HLA-DRB1*08:03:02 and HLA-DQB1*06:01:01 are associated with HMD-sensitive AR and may confer a risk for development of AR in Han Chinese subjects sensitized to HDM.