Brain connectivity
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The default-mode network (DMN) has been implicated in many conditions. One particular function relates to its role in motor preparation. However, the possibly complex relationship between DMN activity and motor preparation has not been fully explored. ⋯ Furthermore, during the intertask intervals of the unpredictable condition, the DMN showed a positive relationship with right sensorimotor cortex and a negative relation with the left sensorimotor cortex. These findings indicate a specific modulation on motor processing according to the state of motor readiness. Therefore, connectivity studies using task-based fMRI to probe DMN should consider the influence of motor system modulation when interpreting the results.