Brain connectivity
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Individuals with nonspecific low back pain (NSLBP) show an impaired sensorimotor control. They need significantly more time to perform five consecutive sit-to-stand-to-sit (STSTS) movements compared with healthy controls. Optimal sensorimotor control depends on the coactivation of many brain regions, which have to operate as a coordinated network to achieve correct motor output. ⋯ However, local efficiency was significantly decreased in the patients with NSLBP compared with controls (p < 0.05, false discovery rate [FDR] corrected). Moreover, global efficiency was significantly correlated with the sensorimotor task performance within the NSLBP group (r = -0.73, p = 0.002). Our data show disrupted network organization of white matter networks in patients with NSLBP, which may contribute to their persistent pain and sensorimotor disabilities.