The journal of trauma and acute care surgery
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J Trauma Acute Care Surg · May 2012
Comparative StudyThe severity of brain damage determines bone marrow stromal cell therapy efficacy in a traumatic brain injury model.
Patients who survive traumatic brain injury (TBI) can undergo serious sensorial and motor function deficits. Once damage occurs, there is no effective treatment to bring patients to full recovery. Recent studies, however, show bone marrow stromal cells (BMSC) as a potential therapy for TBI. ⋯ These findings suggest that the severity of neurologic damage may determine the potential effect of cell therapy when applied to chronically established TBI.
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J Trauma Acute Care Surg · Apr 2012
Comparative StudyComparison of hemodynamic measurements from invasive and noninvasive monitoring during early resuscitation.
Measurements obtained from the insertion of a pulmonary artery catheter (PAC) in critically ill and/or injured patients have traditionally assisted with resuscitation efforts. However, with the recent utilization of ultrasound in the intensive care unit setting, transthoracic echocardiography (TTE) has gained popularity. The purpose of this study is to compare serial PAC and TTE measurements and document levels of serum biomarkers during resuscitation. ⋯ Measurements of CO and SV were moderately strong in correlation and agreement which may suggest PAC measurements overestimate actual values. The significance of tricuspid regurgitation and mitral regurgitation during early resuscitation is unknown.
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J Trauma Acute Care Surg · Apr 2012
Prehospital dynamic tissue oxygen saturation response predicts in-hospital lifesaving interventions in trauma patients.
Tissue oximetry (StO2) plus a vascular occlusion test is a noninvasive technology that targets indices of oxygen uptake and delivery. We hypothesize that prehospital tissue oximetric values and vascular occlusion test response can predict the need for in-hospital lifesaving interventions (LSI). ⋯ Prehospital DeO2 is associated with need for LSI in our trauma population. Further study of DeO2 is warranted to determine whether it can be used as an adjunct triage criterion or an endpoint for resuscitation.