Oral surgery, oral medicine, oral pathology and oral radiology
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Oral Surg Oral Med Oral Pathol Oral Radiol · Mar 2016
Effect of bisphosphonates on macrophagic THP-1 cell survival in bisphosphonate-related osteonecrosis of the jaw (BRONJ).
Immune deficiency and bacterial infection have been suggested to play a role in the pathophysiology of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Zoledronate was previously found to promote THP-1 cell death. To examine this hypothesis with all commonly prescribed bisphosphonates, we tested the effect of (nitrogen-containing) ibandronate, risedronate, alendronate, pamidronate, and (non-nitrogen-containing) clodronate on macrophagic THP-1 cells. ⋯ Commonly prescribed bisphosphonates inhibit the survival of macrophagic THP-1 cells dose-dependently without altering morphology. This may suggest a local immune dysfunction reflective of individual bisphosphonate potency leading to the pathogenesis of BRONJ.
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Oral Surg Oral Med Oral Pathol Oral Radiol · Mar 2016
Association between pterygoid hamulus length and apnea hypopnea index in patients with obstructive sleep apnea: a combined three-dimensional cone beam computed tomography and polysomnographic study.
The purpose of this study was to investigate the relationships among the pterygoid hamulus (PH), the maxillo-mandibular complex to the pharynx, the upper airway, and the soft palate and a possible connection to sleep apnea severity as assessed by polysomnography. ⋯ The pterygoid hamulus length is inversely associated with sleep apnea severity. Our study provides further insight into the pathophysiology of sleep apnea, with the result that PH length could be a future supplementary measurement to help clinicians to stratify and determine the best treatment options for patients with obstructive sleep apnea.
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Oral Surg Oral Med Oral Pathol Oral Radiol · Mar 2015
Randomized Controlled TrialPulsed electromagnetic fields for postoperative pain: a randomized controlled clinical trial in patients undergoing mandibular third molar extraction.
The clinical efficacy of a wearable pulsed electromagnetic field (PEMF) therapy device was assessed in terms of pain and quality of healing after tooth extraction. ⋯ PEMF therapy delivered by a wearable device improved soft tissue healing and may be a useful adjunct for pain management after oral surgery.
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Oral Surg Oral Med Oral Pathol Oral Radiol · Oct 2014
Characteristics of 511 patients with temporomandibular disorders referred for physical therapy.
This study aimed (1) to identify the diagnostic subsets of a patient population with temporomandibular disorders (TMD) referred from dental professionals to a physical therapist (PT) in an outpatient physical therapy practice and (2) to use the characteristics of this TMD population to assist clinical decision making in the management of TMD. ⋯ PTs in an outpatient practice should be proficient in the use of the RDC/TMD. Characteristics identified with this patient population suggest that dentists should involve the services of PTs early in the management of patients with TMD and cervical symptoms.
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Oral Surg Oral Med Oral Pathol Oral Radiol · Aug 2014
Randomized Controlled TrialThe effect of nitrous oxide inhalation on the hypotensive response to propofol: a randomized controlled trial.
Decrease in arterial blood pressure is a prominent adverse reaction during propofol (Disoprivan; AstraZeneca K.K., Osaka, Japan) sedation. The purpose of this prospective randomized study was to explore the effects of nitrous oxide (N2O) on the hypotensive response during propofol sedation. ⋯ Addition of N2O to propofol sedation can attenuate the hypotensive effect of propofol.