Revista española de medicina nuclear e imagen molecular
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Rev Esp Med Nucl Imagen Mol · Mar 2012
Does hyperglycemia affect the diagnostic value of 18F-FDG PET/CT?
Net cellular uptake of (18)F-FDG is adversely affected by elevated plasma glucose levels. The purpose of our study was to investigate the influence of hyperglycemic state at the time of (18)F-FDG injection on the diagnostic accuracy of (18)F-FDG PET/CT. ⋯ Our study suggests that (18)F-FDG accumulation of malignant lesions remains sufficiently high for reliable qualitative clinical diagnosis in chronic and acute hyperglycemic states. However, regarding the discordant and inconclusive results of the available reports and the remarkable concerns with reference to the adverse effects of elevated plasma glucose levels on the diagnostic accuracy of (18)F-FDG PET/CT scans, further direct clues seems to be required and should be provided by future studies.