JAMA pediatrics
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Randomized Controlled Trial Multicenter Study
Baseline factors predicting placebo response to treatment in children and adolescents with autism spectrum disorders: a multisite randomized clinical trial.
The finding of factors that differentially predict the likelihood of response to placebo over that of an active drug could have a significant impact on study design in this population. ⋯ This analysis suggests strategies that may be useful in anticipating and potentially mitigating the nonspecific response in randomized clinical trials of children and adolescents with autism spectrum disorders.