The Mount Sinai journal of medicine, New York
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An effective response to injury or inflammation requires leukocyte migration from the endovascular compartment into areas of inflammation. This process requires the appropriate expression of adhesion molecules, which mediate cell-cell and cell-extracellular matrix interactions. ⋯ The role of cell adhesion molecules in a variety of pathological conditions, including graft rejection, reperfusion injury, and acute lung injury are discussed. In addition, some recent studies that explore therapeutic uses of adhesion molecules are summarized.