European journal of pharmacology
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Comparative Study
Comparative effects of vitamin D and methylprednisolone against ischemia/reperfusion injury of rabbit spinal cords.
Recent studies have demonstrated the neuroprotective and immunomodulatory effects of 1,25-dihydroxyvitamin D3 (calcitriol), but no previous study has examined these effects on spinal cord ischemia/reperfusion (I/R) injury. Therefore, the present study aimed to evaluate whether calcitriol protects the spinal cord from I/R injury. ⋯ Calcitriol pretreatment provided significant neuroprotective benefits following spinal cord I/R injury.