European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Mar 1976
Randomized Controlled Trial Comparative Study Clinical TrialEffect of paracetamol, mephenoxalone and their combination on pain following bone surgery.
Sixty patients suffering moderate postoperative pain after bone surgery were divided randomly into 3 treatment groups on the day following operation. Under double blind conditions they received either 400 mg mephenoxalone, a weak sedative, or 900 mg paracetamol, or the same doses of these drugs simultaneously, three times daily for three days. ⋯ However, during repeated administration over 3 days, the mean effect of the drug combination was slightly better than that of paracetamol or mephenoxalone alone. The drug combination did not induce more sedation or gastrointestinal side effects than either drug alone.