European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Nov 1999
Randomized Controlled Trial Clinical TrialAssessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections.
The aim of this study was to assess and compare the efficacy and tolerability of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections (URTIs). ⋯ The results of this study demonstrated that the anti-pyretic effectiveness of nimesulide is better than paracetamol and ibuprofen in febrile children with URTIs. However, new studies in larger paediatric populations are required to explore the anti-inflammatory effect of nimesulide.
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Eur. J. Clin. Pharmacol. · Nov 1999
Opioid consumption in Spain--the significance of a regulatory measure.
To investigate the impact of new regulatory measures on opioid consumption in Spain during the period 1985-1998. ⋯ A huge increase in opioid consumption has occurred. In this increase, changes in supply and, to a lesser extent, regulatory measures have played an important role.