European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Oct 2001
Randomized Controlled Trial Clinical TrialAcetaminophen analgesia in children: placebo effect and pain resolution after tonsillectomy.
Pharmacodynamic models of acetaminophen analgesia in children have not explored the efficacy of single oral doses greater than 40 mg/kg. ⋯ High dose acetaminophen (100 mg/kg) was no more effective than 40 mg/kg and was associated with increased nausea and vomiting. A target effect compartment concentration of 10 mg/l is expected to produce a pain reduction of 2.6 units. The placebo model accounted for a maximum pain reduction of 5.6 units at 3 h. The combination of placebo effect and preoperative acetaminophen 40 mg/kg results in pain scores below 4 units for 5 h postoperatively.