European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Aug 2001
Randomized Controlled Trial Comparative Study Clinical TrialPharmacokinetics and pharmacodynamics of epoetin alfa once weekly and three times weekly.
To compare the pharmacokinetics, pharmacodynamics, and tolerance of epoetin alfa administered subcutaneously (s.c.) once weekly (q.w.) and three times weekly (t.i.w.). ⋯ The pharmacodynamic responses were equivalent between groups despite expected differences in total erythropoietin exposure. These results indicate that the epoetin alfa 150 IU/kg t.i.w. and 40,000 IU q.w. regimens can be considered clinically equivalent.