European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Jul 2002
ReviewMicrodialysis: an in vivo approach for measuring drug delivery in oncology.
Microdialysis (MD) is a catheter-based sampling method that provides the opportunity to directly study tumor drug exposure and metabolism in a minimally invasive way. Tumor drug exposure, which is directly linked to clinical outcome, may be substantially reduced due to diffusion barriers in solid tumors. ⋯ This contribution focuses on the application of MD in preclinical and clinical oncological research and presents an overview of the current literature. It is concluded that MD, in combination with pharmacokinetic/pharmacodynamic modeling, has the potential to contribute to the design of optimal treatment schedules and to select appropriate drug candidates, doses, and dosing intervals for established and new anticancer drugs.
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Eur. J. Clin. Pharmacol. · Jul 2002
Admissions caused by adverse drug events to internal medicine and emergency departments in hospitals: a longitudinal population-based study.
To estimate incidence rates of drug-related hospitalizations (DRHs) in a longitudinal population-based study with prospective event assessment. ⋯ DRHs are a considerable public health and economic burden. A longitudinal design can observe changes in population-based incidence over time. This approach can be used for public-health planning or to evaluate outcomes of quality management programs designed to reduce drug-induced illness.