European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Nov 2007
Randomized Controlled Trial Comparative StudyLevocetirizine does not prolong the QT/QTc interval in healthy subjects: results from a thorough QT study.
To conduct a thorough QT study of levocetirizine, a non-sedating antihistamine, in accordance with International Conference on Harmonisation (ICH) E14 guidance. ⋯ Overall, the results of this thorough QT study indicate that the methodology of the trial was valid and sensitive enough to demonstrate the absence of effect of levocetirizine at both therapeutic (5 mg) and supra-therapeutic (30 mg) doses on cardiac repolarisation.