European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Apr 2007
Use of anti-asthmatic drugs during pregnancy. 3. Congenital malformations in the infants.
To study the risk for congenital malformations among infants whose mothers used anti-asthmatic drugs during pregnancy. ⋯ Maternal asthma and use of anti-asthmatic drugs carry no major risk for congenital malformations in the offspring, but a slight teratogenic effect cannot be excluded. It may be due to asthma, and arguments for a stronger effect of inhaled corticosteroids than of other anti-asthmatics are weak.
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Eur. J. Clin. Pharmacol. · Apr 2007
Randomized Controlled TrialEarly-phase pharmacokinetics of enteral and parenteral nimodipine in patients with acute subarachnoid haemorrhage - a pilot study.
The pharmacokinetics of nimodipine following enteral administration in the early phase after subarachnoid haemorrhage (SAH) has not been described. If a sufficient absorption could be achieved with enterally administered nimodipine, this would be more feasible dosage form and result in a significant reduction in pharmaceutical costs given that the parenteral formulation of nimodipine currently used is tenfold more expensive than the enteral formulation. ⋯ This pilot study indicates that the rate and extent of nimodipine absorption following enteral administration in some acute SAH patients could be negligible, and this may particularly be the case in patients with a decreased level of consciousness.