European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Sep 2010
Meta AnalysisHaemodynamics of intravenous paracetamol in neonates.
Reports on the haemodynamics of intravenous (iv) paracetamol in adult intensive care were recently published. We therefore wanted to explore the haemodynamics of iv paracetamol in neonates. ⋯ In a setting of open label administration to alleviate (procedural) pain, haemodynamic effects of iv paracetamol in neonates remained modest. We suggest considering impaired haemodynamics to be a relative contra-indication for iv paracetamol in neonates.
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Eur. J. Clin. Pharmacol. · Sep 2010
A signal for an abuse liability for pregabalin--results from the Swedish spontaneous adverse drug reaction reporting system.
Pregabalin is a gamma-aminobutyric acid (GABA) analogue approved for the treatment of epilepsy, neuropathic pain and generalised anxiety disorder. As a GABA analogue, there has been some concern about an abuse liability. We aimed to investigate the possible abuse liability of pregabalin. ⋯ Based on the signal from the present study, we conclude that pregabalin is likely to be associated with an abuse potential.