European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Oct 2011
Multicenter Study Clinical TrialBuprenorphine versus methadone in pregnant opioid-dependent women: a prospective multicenter study.
In order to investigate the effects of exposure to buprenorphine compared with methadone during pregnancy, a prospective multicenter study was conducted in collaboration with maternity hospitals, maintenance therapy centers, and general practitioners involved in addiction care. Ninety pregnant women exposed to buprenorphine and 45 to metadone were selected for the study. ⋯ We did not observe more frequent malformations or cases of withdrawal syndrome in the buprenorphine group than in the methadone-treated group. Buprenorphine appears to be as safe as the currently approved substitute methadone considered to date as the reference treatment for pregnant opioid-dependent women.