European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Mar 2011
Randomized Controlled Trial Comparative StudyInteraction between acetaminophen and warfarin in adults receiving long-term oral anticoagulants: a randomized controlled trial.
We investigated whether acetaminophen, given at 2 g/day and 3 g/day might potentiate the anticoagulant effect of warfarin. ⋯ Acetaminophen, at 2 g/day or 3 g/day, enhanced the anticoagulant effect of warfarin in stable patients, thus requiring close INR monitoring in the clinical setting.
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Eur. J. Clin. Pharmacol. · Mar 2011
Comparative StudyMultiple outcomes associated with the use of metformin and sulphonylureas in type 2 diabetes: a population-based cohort study in Italy.
To compare the effect of metformin and sulphonylureas on the risks of switching to insulin therapy, hospitalisation for macrovascular disease and all-cause mortality. ⋯ Our study provides evidence that the risks of switching to insulin, hospitalisation because of macrovascular events and death changes according to the first prescribed oral hypoglycaemic agent, as well as to the early compliance and persistence with such agent.
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Eur. J. Clin. Pharmacol. · Mar 2011
Adverse events following immunization in children: retrospective analysis of spontaneous reports over a decade.
There is no doubt that paediatric immunization prevents serious diseases, but the administration of these vaccines to healthy children also involves risks of adverse drug reactions (ADRs), some of which are potentially serious. The current body of evidence on ADRs from immunization therapy at the population level is partly contradictory across countries, time periods and childhood immunization programmes. The objective of our study was to characterize reported adverse events (AEFIs) following immunization in Danish children. ⋯ In Denmark, a large number of AEFIs following paediatric immunization have been reported, but the majority of cases were non-serious.