European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Dec 2014
Reported ingested dose of paracetamol as a predictor of risk following paracetamol overdose.
To evaluate reported ingested dose of paracetamol as a risk assessment tool in acute paracetamol overdose. ⋯ There is a positive correlation between reported ingested dose of paracetamol and subsequent chance of a PPC being above a defined treatment line; however, ingested dose of paracetamol alone is a poor risk assessment tool in accurately determining need for treatment with an antidote.
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Eur. J. Clin. Pharmacol. · Dec 2014
ReviewDrug shortages in developed countries--reasons, therapeutic consequences, and handling.
Drug shortages in developed countries pose a serious public health problem and have far-reaching implications for healthcare providers and their patients. Given the current state of the market, with the limited number of manufacturers and the array of manufacturing quality issues, drug shortages have become a global concern, forcing regulatory authorities to explore and implement strategies to prevent and mitigate drug shortages.