European journal of clinical pharmacology
-
Eur. J. Clin. Pharmacol. · May 2015
Randomized Controlled Trial Multicenter StudyCombination paracetamol and ibuprofen for pain relief after oral surgery: a dose ranging study.
Combined paracetamol and ibuprofen has been shown to be more effective than either constituent alone for acute pain in adults, but the dose-response has not been confirmed. The aim of this study was to define the analgesic dose-response relationship of different potential doses of a fixed dose combination containing paracetamol and ibuprofen after third molar surgery. ⋯ All doses of the combination provide safe superior pain relief to placebo in adult patients following third molar removal surgery.