European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Aug 2015
ReviewPotential cardiovascular adverse events when phenylephrine is combined with paracetamol: simulation and narrative review.
Increased bioavailability of phenylephrine is reported when combined with paracetamol in over-the-counter formulations for the symptomatic treatment of the common cold and influenza. Such formulations could increase phenylephrine-related cardiovascular adverse events particularly in susceptible individuals. Quantification of the effect of phenylephrine concentration on blood pressure allows simulation of potential adverse combination therapy effects. ⋯ Combination paracetamol phenylephrine oral therapy has potential to increase blood pressure more than phenylephrine alone in those with cardiovascular compromise.