European journal of clinical pharmacology
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Eur. J. Clin. Pharmacol. · Feb 2005
Pharmacokinetics of intravenous paracetamol in children and adolescents under major surgery.
The aim of this study was to describe the pharmacokinetics of paracetamol (acetaminophen) and to get primary information on its metabolism after first indicated intravenous administration of paracetamol in children and adolescents undergoing major surgery. ⋯ Surgery, with all its potential influencing factors, together with chemotherapy given about 4 weeks previously do not seem to have a major impact on the pharmacokinetic behavior and the between-subject variability of paracetamol after intravenous administration.
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Eur. J. Clin. Pharmacol. · Oct 2004
Requirements for a successful implementation of drug interaction information systems in general practice: results of a questionnaire survey in Germany.
To determine drug interaction information requirements in general practice with respect to both content and mode of presentation. ⋯ General practitioners wish for more informative support on drug interactions, especially concerning management. Despite a trend towards electronic information sources, printed documents are presently still required to reach all prescribers.
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Eur. J. Clin. Pharmacol. · Oct 2004
Premedication medicines do not cause drug metabolic interaction with propofol using human liver microsomes in vitro.
Propofol (2,6-diisopropylphenol) is widely used for anesthetic induction as well as for chronic sedation in intensive care units. In this study, we investigated the interaction between propofol and premedications, i.e., psychotropic and antianxiety agents (diazepam, midazolam), hypnotics (thiamylal), local anesthetics (lidocaine), depolarizing muscular relaxants (vecuronium), an antihypertensive (clonidine) and an H2-receptor antagonist (cimetidine) using human liver microsomes in vitro. ⋯ These results showed no interactions between propofol and seven premedication drugs within the therapeutic range of propofol using human liver microsomes in vitro.