The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Nov 1995
Randomized Controlled Trial Clinical TrialEffect of six-hour exposure to nitrogen dioxide on early-phase nasal response to allergen challenge in patients with a history of seasonal allergic rhinitis.
Recent studies have suggested that exposure to air pollutants may enhance the airway responsiveness of susceptible individuals to inhaled allergen. ⋯ These results suggest that acute exposure to NO2 at concentrations found at the curbside in heavy traffic during episodes of pollution, may "prime" eosinophils for subsequent activation by allergen in individuals with a history of seasonal allergic rhinitis.
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J. Allergy Clin. Immunol. · Nov 1995
Randomized Controlled Trial Clinical TrialEphedrine-saline nasal wash in allergic rhinitis.
Ephedrine nasal wash (0.25% to 1%) was once used in the treatment of sinusitis and other nasal and paranasal symptoms, but there are no reported controlled trials in allergic rhinitis. ⋯ A 1% ephedrine-saline nasal wash is an inexpensive and effective treatment for allergic rhinitis.
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J. Allergy Clin. Immunol. · Nov 1995
Multicenter StudyStudies on the relationship between the level of specific IgE antibodies and the clinical expression of allergy: I. Definition of levels distinguishing patients with symptomatic from patients with asymptomatic allergy to common aeroallergens.
The detection of specific IgE antibodies to environmental allergens does not always coincide with a diagnosis of clinically evident allergic disease, because some patients with positive skin and/or in vitro test results have no symptoms related to the allergen or allergens that induced the antibodies. ⋯ Cutoff values for specific serum IgE antibody levels are likely to be useful in clinical practice to distinguish symptomatic from asymptomatic allergy in patients with positive skin test results.