The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Aug 1996
Randomized Controlled Trial Clinical TrialIncreased sensitivity to bradykinin among African Americans.
Angioedema is a potentially life-threatening side effect of angiotensin-converting enzyme (ACE) inhibitors. Although the mechanism of angioedema is not certain, bradykinin has been implicated in its pathogenesis. Compared with Caucasians, African Americans are at an increased risk of ACE inhibitor-associated angioedema, independent of ACE inhibitor dose or concurrent medications. Because urinary kallikrein levels are decreased in African Americans with hypertension, we hypothesized that endogenous bradykinin levels may be decreased in African Americans and that they therefore may be more sensitive to ACE inhibitor-induced increases in bradykinin or to exogenous bradykinin. ⋯ These data provide additional support for racial differences in the kallikrein-kinin system and also implicate abnormalities of the tissue kallikrein-kinin system in essential hypertension.
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J. Allergy Clin. Immunol. · Aug 1996
Letter Case ReportsAccupril- and Cozaar-induced angioedema in the same patient.