The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Aug 1997
Randomized Controlled Trial Multicenter Study Clinical TrialNebulized salbutamol with and without ipratropium bromide in the treatment of acute asthma.
Routine addition of ipratropium bromide to beta-agonist therapy in acute asthma is of uncertain benefit. ⋯ A single dose of nebulized Combivent confers additional bronchodilation over salbutamol alone (p < 0.05) in acute asthma. Patients who exhibited most benefit from the addition of ipratropium were those who had consumed the least inhaled beta-agonist before presentation, not those with the most severe asthma.