The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Mar 2000
Multicenter Study Clinical Trial Controlled Clinical TrialHazelnut allergy: a double-blind, placebo-controlled food challenge multicenter study.
Tree nuts are a common cause of food allergy in Europe. However, few studies deal with real food allergy to hazelnuts in subjects believed to be allergic to this food. ⋯ This study shows that hazelnut is an allergenic source that can cause real food allergy, as confirmed by DBPCFC. Skin and IgE tests demonstrated reasonable sensitivity and PPV but a very low specificity and NPV, thus implying that these should not be used to validate the diagnosis of food allergy to hazelnut.