The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Jul 2002
Endotoxins prevent murine IgE production, T(H)2 immune responses, and development of airway eosinophilia but not airway hyperreactivity.
Contact with immunomodulatory factors, such as LPS, in early infancy is associated with decreased allergen sensitization. ⋯ These data indicate that local and systemic application of LPS modulates systemic and local T(H)1/T(H)2 immune responses in a distinct but similarly IL-12-dependent mode.
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J. Allergy Clin. Immunol. · Jul 2002
Clinical significance of bronchoalveolar eosinophils in childhood asthma.
To evaluate the relationship between clinical parameters and differential cell counts, bronchoalveolar lavage was performed in 79 asthmatic infants and children with unusual asthma. Multivariate analysis showed significant associations between (1) allergic asthma and the presence of alveolar eosinophils and (2) persistent and longer asthma and an increased number of alveolar neutrophils. Our results provide the first evidence that in asthmatic infants and children eosinophilic inflammation is related to allergic sensitization.