The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Dec 2003
Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids.
Matrix metalloproteinase (MMP)-9 levels are increased in bronchoalveolar lavage (BAL) fluid from patients with severe asthma on high doses of glucocorticoids (GCs). ⋯ BAL neutrophils contribute to BAL fluid MMP-9 protein and activity and are poorly inhibited by GCs.