The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Aug 2003
Impulse oscillometry provides an effective measure of lung dysfunction in 4-year-old children at risk for persistent asthma.
Objective lung function measurements are routinely used to diagnose and manage asthma, but their utility for young children has not been defined. ⋯ IOS bronchodilator responses are remarkably abnormal in 4-year-old children, who are most likely to have persistent asthma. IOS is a useful diagnostic tool in early asthma development and might be a helpful objective outcome measure of early interventions.
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J. Allergy Clin. Immunol. · Aug 2003
Randomized Controlled Trial Clinical TrialThe effects of an anti-CD11a mAb, efalizumab, on allergen-induced airway responses and airway inflammation in subjects with atopic asthma.
Efalizumab is a humanized IgG(1) mAb against the lymphocyte function antigen-1 (LFA-1) alpha chain, CD11a. Blocking of LFA-1/intercellular adhesion molecule interactions could inhibit asthmatic inflammation by blocking adhesion and activation of LFA-1-positive leukocytes. ⋯ Blocking of LFA-1/intercellular adhesion module interactions by efalizumab inhibits the development of allergen-induced cellular inflammatory responses measured in induced sputum and might attenuate the late asthmatic response. Larger studies are needed to confirm this.