The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Nov 2005
Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease.
Reactive nitrogen species, formed via the reaction of nitric oxide (NO) with superoxide anion and via (myelo)peroxidase-dependent oxidation of NO(2)(-), have potent proinflammatory and oxidizing actions. Reactive nitrogen species formation and nitrosative stress are potentially involved in chronic obstructive pulmonary disease (COPD) pathogenesis. ⋯ These data suggest that nitrosative stress, mainly mediated by MPO and neutrophilic inflammation, may contribute to the pathogenesis of severe COPD.