The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · May 2005
Comparative StudyRelationships among quality of life, severity, and control measures in asthma: an evaluation using factor analysis.
Validated psychometric tools measuring quality of life, asthma control, and asthma severity have been developed, but their relationships with each other and with other important patient-centered outcomes have not been rigorously assessed. ⋯ Distinct components of patient-reported asthma health status can be identified by factor analysis. Distinct constructs of severity versus control cannot be identified by the use of these tools alone.
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J. Allergy Clin. Immunol. · May 2005
Comparative StudyIgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis.
Autoreactivity of patients with atopic dermatitis (AD) to human proteins has been postulated as a decisive pathogenetic factor for AD. ⋯ Human MnSOD may play a role as an autoallergen in a subset of patients with AD, including nonatopic eczema. By molecular mimicry leading to cross-reactivity such sensitization might be induced primarily by exposure to environmental fungal MnSOD of M sympodialis .