The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Oct 2006
Randomized Controlled TrialSalmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma.
Recent studies suggest that there might be an association between albuterol use and worsening asthma in patients homozygous for arginine (Arg/Arg) at codon 16 of the beta-receptor. However, it is not known whether similar responses occur in Arg/Arg patients receiving long-acting beta2-agonists. ⋯ Analyses from this study indicate that genetic polymorphisms leading to Arg16Gly sequence changes within the beta2-adrenergic receptor do not affect patients' responses to recommended asthma therapy with salmeterol and fluticasone propionate.